Why is this medication prescribed? Trazodone is used to treat depression. Trazodone is in a class of medications called serotonin modulators. It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance. Trazodone is an antidepressant that belongs to a group of medicines called serotonin modulators. It works by increasing the amount of serotonin, a natural chemical in the brain. Trazodone is used to treat major depressive disorder. It may help to improve your mood, appetite, and energy level as well as decrease anxiety and insomnia related to depression. Trazodone is an antidepressant that is sometimes prescribed as a sleep aid. It is not addictive and may offer additional benefits over other sleep aids for certain conditions, such as sleep apnea. Medical uses Depression The primary use of trazodone is the treatment of unipolar major depression with or without anxiety. [4] Data from open and double-blind trials suggest that the antidepressant efficacy of trazodone is comparable to that of amitriptyline, doxepin, and mianserin. Trazodone is FDA-approved for major depressive disorder but predominantly prescribed off-label for insomnia. At low doses (25–100 mg), it produces sedation. Higher doses (150–600 mg) are needed for antidepressant efficacy but increase orthostatic hypotension and sedation, limiting tolerability. Trazodone is used to treat depression. It is thought to work by increasing the activity of serotonin in the brain. Trazodone is an antidepressant. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Trazodone is used to manage depression, insomnia, and anxiety through increased serotonin action in the brain. Although effective, it's essential to discuss potential interactions and side effects with a healthcare provider. Trazodone is a prescription medication used to treat depression. Learn about side effects, dosages, drug interactions, warnings, and more. Trazodone treats depression. Dosage varies, up to a maximum of 400 mg per day. Avoid negative side effects by following your prescriber’s instructions.